Argireline

Acetyl Hexapeptide-8 Amide

Evidence & Status

  • Preliminary / Experimental
  • Preliminary

At a Glance

A topical cosmetic peptide studied for the appearance of facial wrinkles. Human findings are small and mixed; results do not establish a Botox-like effect.

Plain English

Argireline appears in some wrinkle serums. One small controlled study reported improvement, while a later small serum study did not show a statistically significant benefit from adding Argireline. Results depend on the formulation tested.

Overview

Argireline is a name for acetyl hexapeptide-8 amide, a synthetic six-amino-acid peptide used in topical cosmetic research. This entry concerns skin-applied products, not injections or an approved wrinkle-treatment drug.

Research Summary

A randomized, placebo-controlled study enrolled 60 people and reported improvements in wrinkle appearance with its tested Argireline formulation. A later, 19-person facial-serum study found no statistically significant difference attributable to Argireline. These studies do not establish consistent results across products, long-term benefit, or equivalence to botulinum toxin.

Research Areas

  • Facial-wrinkle appearance
  • Topical cosmetic peptides
  • Skin-care formulations
United States
Topical cosmetic ingredient; no FDA-approved drug indication established for Argireline. FDA does not generally preapprove cosmetic ingredients.
United Kingdom
Current authorization status not established in this record.
Australia
Current authorization status not established in this record.
Canada
Current authorization status not established in this record.

Citations & Sources