CJC-1295

CJC-1295 with DAC (Drug Affinity Complex)

Evidence & Status

  • Preliminary / Experimental
  • Preliminary

At a Glance

A modified growth hormone-releasing hormone analogue studied for its ability to extend the body's natural growth hormone release signals. Commonly explored in research on growth hormone biology, body composition, and metabolic health.

Plain English

Researchers study CJC-1295 because it mimics a natural hormone signal — known as growth hormone-releasing hormone — that normally prompts the body to produce growth hormone in short bursts. Scientists are interested in what happens when these signals are extended over a longer period, and how that might relate to body composition and metabolism over time. It is frequently studied in combination with Ipamorelin, as the two compounds are thought to work through complementary pathways in growth hormone biology.

Overview

A modified GHRH analogue containing a Drug Affinity Complex (DAC) designed to prolong exposure through albumin binding. This record covers the DAC molecule only; it does not cover non-DAC “modified GRF” products, which have different pharmacokinetics.

Research Summary

A placebo-controlled healthy-adult study found prolonged, dose-dependent increases in growth hormone and IGF-1 after CJC-1295 with DAC. That pharmacodynamic finding does not establish benefit for aging, body composition, athletic performance, or other clinical outcomes, and it must not be generalized to non-DAC products.

Research Areas

  • Growth hormone axis
  • Muscle hypertrophy
  • Fat metabolism
  • Anti-aging
  • IGF-1 modulation

Safety & Risks

Serious Risks

  • Sustained pharmacologic growth-hormone and IGF-1 changes were reported in early studies; long-term clinical safety and outcomes have not been established

Reported Side Effects

  • Water retention
  • Tingling/numbness
  • Flushing at injection
  • Headache
  • Possible desensitization of GHRH receptors
United States
Research only
United Kingdom
Research only
Australia
Research only
Canada
Research only

Citations & Sources