GHRP-2
Growth Hormone Releasing Peptide-2 (Pralmorelin)
Evidence & Status
- Moderate Evidence
- Moderate
At a Glance
A synthetic growth hormone secretagogue studied in controlled human GH-response, diagnostic, and appetite research. The cited studies do not establish a general therapeutic regimen, long-term safety, or superiority to other secretagogues.
Plain English
Researchers study GHRP-2 because controlled human studies have examined its acute growth-hormone response, use in diagnostic testing, and effects on food intake. These studies do not establish a general treatment use, long-term safety profile, comparison with other secretagogues, or a regulatory approval claim in this record.
Overview
GHRP-2 (pralmorelin) is a synthetic hexapeptide growth-hormone secretagogue studied in controlled human endocrine and diagnostic research. The verified sources support acute GH-response and diagnostic-context observations. They do not establish superiority to other secretagogues, a cortisol/prolactin profile, long-term body-composition outcomes, or a general treatment regimen.
Research Summary
GHRP-2 has controlled human endocrine and diagnostic research, including GH-response studies and adult GH-deficiency testing; one cited study reported increased food intake in healthy men. The published evidence in this record does not establish a preferred therapeutic use, chronic safety, anti-aging benefit, body-composition outcome, or recommendation-style dosing.
Research Areas
- Growth hormone response research
- Diagnostic growth hormone testing
- Appetite research
Safety & Risks
Serious Risks
- Long-term clinical safety and therapeutic outcomes are not established by the cited studies.
Reported Side Effects
- Increased food intake in healthy men
Legal Status by Region
- United States
- Research chemical; not FDA-approved for human use
- United Kingdom
- Current authorization status not established in this record
- Australia
- Current authorization status not established in this record
- Canada
- Current authorization status not established in this record
Citations & Sources
- Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise.
Wideman L et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 2000
PMID 11004017 · DOI 10.1152/ajpregu.2000.279.4.R1467
- A simple diagnostic test using GH-releasing peptide-2 in adult GH deficiency.
Chihara K et al. · European Journal of Endocrinology · 2007
PMID 17609397 · DOI 10.1530/EJE-07-0066
- Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men.
Laferrère B et al. · The Journal of Clinical Endocrinology and Metabolism · 2005
PMID 15699539 · DOI 10.1210/jc.2004-1719