Pinealon
Pinealon (EDR Brain-Directed Tripeptide)
Evidence & Status
- Preliminary / Experimental
- Preliminary
At a Glance
A synthetic tripeptide studied primarily in preclinical and in-vitro research. The current evidence set does not establish human effects on cognition, aging, neuroprotection, or retinal disease.
Plain English
Researchers study Pinealon because it is a short peptide associated with the pineal gland — the brain structure involved in melatonin production and circadian rhythm regulation. The current cited research is limited to preclinical and in-vitro work, including animal behavior/neurochemistry and cell-based experiments. Those sources do not establish human clinical effects on cognition, aging, neuroprotection, or retinal health.
Overview
Pinealon/EDR is a synthetic tripeptide with published evidence in this record limited to preclinical and in-vitro research. The verified sources concern EDR context, aged-rat behavioral and neurochemical experiments, cell viability/free-radical assays, and short-peptide antihypoxic studies. Human cognition, anti-aging, neuroprotection, and gene-expression benefits are not established by these sources.
Research Summary
Pinealon/EDR remains preliminary. Verified research is preclinical or in vitro and includes aged-rat behavior/neurochemistry, cell viability and free-radical assays, and antihypoxic short-peptide work. Human cognition, anti-aging, neuroprotection, and gene-expression claims are not established.
Research Areas
- Preclinical neurochemical and cellular research
- Short-peptide antihypoxic research
Safety & Risks
Serious Risks
- Primarily animal and in vitro evidence; insufficient human clinical data; all evidence derives largely from Russian laboratory studies with limited independent replication
Legal Status by Region
- United States
- Research only
- United Kingdom
- Current authorization status not established in this record
- Australia
- Current authorization status not established in this record
- Canada
- Current authorization status not established in this record
Citations & Sources
- EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease.
Khavinson V, Linkova N, Kozhevnikova E, Trofimova S · Molecules (Basel, Switzerland) · 2020
PMID 33396470 · DOI 10.3390/molecules26010159
- [Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia].
Mendzheritsky AM, Karantysh GV, Ryzhak GA, Prokofiev VN · Advances in gerontology = Uspekhi gerontologii · 2015
PMID 28509493
- Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes.
Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A, Boldyrev A · Rejuvenation research · 2011
PMID 21978084 · DOI 10.1089/rej.2011.1172
- [Investigation of antihypoxic properties of short peptides].
Kozina LS · Advances in gerontology = Uspekhi gerontologii · 2008
PMID 18546825